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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Talc (inhaled, sniffed, i.v., intrapleural)

3

XV.q Path: Foreign body deposits/granulomatous reaction

2
Last update : 07/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Marijuana, cannabis (haschish, hash, bang, dab)
5

Publications

Persistent Inflammation in Pulmonary Granuloma 48 Years after Talcage Pleurodesis, Detected by FDG-PET/CT.
Case reports in medicine 2012;2012;686153 2012
A 29-year-old woman with a remote history of osteosarcoma and positron emission tomography-positive pleurally based masses. Talcomas secondary to prior talc pleurodesis.
Chest 2008 Sep;134;640-643 2008 Sep
Interstitial lung disease in an intravenous drug user.
Respiration; international review of thoracic diseases 2003;70;101-3 2003
Talc granulomatosis. A differential diagnosis of interstitial lung disease in HIV patients.
Chest 2000 Jul;118;258-60 2000 Jul

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