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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Carboplatin

3

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

3
Last update : 11/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Cisplatin
3
Oxaliplatin
3
Oxaliplatin-based regimens
4
Platinum salts
3

Publications

Hypersensitivity reactions to carboplatin and cisplatin in non-small cell lung cancer.
Journal of thoracic disease 2013 Apr;5;E53-7 2013 Apr
Carboplatin-induced hypersensitivity reaction.
Case reports in oncology 2012 Jan;5;141-2 2012 Jan
Desensitization treatment with cisplatin after carboplatin hypersensitivity reaction in gynecologic cancer.
The journal of medical investigation : JMI 2010 Feb;57;163-7 2010 Feb
Hypersensitivity following Retreatment with Carboplatin a Decade after Completion of Primary Platinum-Based Chemotherapy.
Case reports in oncology 2009 Feb 20;2;20-23 2009 Feb 20
Successful desensitization to carboplatin in patients with systemic hypersensitivity reactions.
Medical and pediatric oncology 1996 Feb;26;105-10 1996 Feb
Hypersensitivity reactions to carboplatin. Report of two patients, review of the literature, and discussion of diagnostic procedures and management.
Cancer 1994 Apr 15;73;2218-22 1994 Apr 15

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