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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Lamotrigine

1

X.a DRES syndrome - DRESS-like reaction

1
Last update : 17/04/2012
 
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Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Anticonvulsants
3

Publications

Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2023 Oct 25;19;92 2023 Oct 25
Bronchiolitis obliterans organising pneumonia associated with anticonvulsant hypersensitivity syndrome induced by lamotrigine.
BMJ case reports 2016 Jan 29;2016; 2016 Jan 29
Lamotrigine-induced anticonvulsant hypersensitivity syndrome associated with acute respiratory distress syndrome.
Psychosomatics 2011;52;495-7 2011
Dress syndrome and fulminant hepatic failure induced by lamotrigine.
Annals of hepatology 2009;8;75-7 2009
Lamotrigine-associated anticonvulsant hypersensitivity syndrome in bipolar disorder.
Progress in neuro-psychopharmacology & biological psychiatry 2006 Jun;30;741-4 2006 Jun
Idiosyncratic drug reactions: the reactive metabolite syndromes.
Lancet (London, England) 2000 Nov 04;356;1587-91 2000 Nov 04
Severe hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro.
Allergy 2000 Feb;55;191-3 2000 Feb

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