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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Warfarin

5

IV.af Calcification of tracheobronchial cartilaginous rings

2
Last update : 14/07/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Anticoagulants, oral (vitamin K antagonists-VKA)
5
Cocaine
5
Heroin (inhaled, insufflated, snorted)
4
Heroin (intravenous)
5
Superwarfarins (vitamin K super antagonist rodenticides)
4

Publications

Warfarin-Associated Tracheobronchial Calcification.
American journal of therapeutics 2019;26;e787-e788 2019
Calciphylaxis.
The New England journal of medicine 2018 May 03;378;1704-1714 2018 May 03
Tracheobronchial calcification due to warfarin therapy.
American journal of respiratory and critical care medicine 2014 Jun 15;189;e73 2014 Jun 15
Two cases of warfarin-induced tracheobronchial calcification after Fontan surgery.
Pediatric cardiology 2014 Aug;35;954-8 2014 Aug
Warfarin-induced tracheobronchial calcification.
Journal of thoracic imaging 2003 Apr;18;110-2 2003 Apr
CT detection of tracheobronchial calcification in an 18-year-old on maintenance warfarin sodium therapy: cause and effect?
AJR. American journal of roentgenology 2000 Sep;175;921-2 2000 Sep
Tracheal and bronchial cartilaginous rings: warfarin sodium-induced calcification.
Radiology 1992 Aug;184;437-9 1992 Aug

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