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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Warfarin

5

XII.ar Calcification of the coronary artery walls or atheroma

1
Last update : 15/08/2017
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Abused drugs/substances (illicit-, street drugs - IV/inhaled)
5
Anticoagulants, oral (vitamin K antagonists-VKA)
5
Cocaine
5
Heroin (inhaled, insufflated, snorted)
4
Heroin (intravenous)
5
Superwarfarins (vitamin K super antagonist rodenticides)
4

Publications

Warfarin Use Is Associated With Progressive Coronary Arterial Calcification: Insights From Serial Intravascular Ultrasound.
JACC. Cardiovascular imaging 2018 Sep;11;1315-1323 2018 Sep
Calciphylaxis.
The New England journal of medicine 2018 May 03;378;1704-1714 2018 May 03

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