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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Colistin-Colimycin

2

IX.a Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

2
Last update : 13/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antibiotics
5
Colistimethate
1
Colistin, inhaled
3

Publications

[Severe respiratory failure and neuromuscular blockade after administration of colimycin].
Medicina intensiva 2015 Oct;39;448-9 2015 Oct
Sudden respiratory muscle paralysis and apnea in a patient infected with multidrug-resistant Pseudomonas aeruginosa treated with intravenous colistin.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2013 May;17;e357 2013 May
Intravenous and inhalational colistin-induced respiratory failure.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010 Mar 15;50;e38-40 2010 Mar 15
Adverse effects of drugs on the respiratory muscles.
Clinics in chest medicine 1990 Mar;11;177-89 1990 Mar

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