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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Anticonvulsants

3

X.a DRES syndrome - DRESS-like reaction

3
Last update : 12/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Carbamazepine
3
Lamotrigine
1
Levetiracetam
1
Phenobarbital
2
Phenytoin (diphenylhydantoin)
4
Valproate (Valproic acid)
2

Publications

Drug reaction with eosinophilia and systemic symptoms syndrome is not uncommon and shows better clinical outcome than generally recognised.
Allergologia et immunopathologia 2015;43;19-24 2015
Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs.
European journal of clinical pharmacology 2011 May;67;463-70 2011 May
The DRESS syndrome: a literature review.
The American journal of medicine 2011 Jul;124;588-97 2011 Jul
Drug reaction with eosinophilia and systemic symptoms induced by carbamazepine: DRESSed to kill.
General hospital psychiatry 2011;33;412.e5-8 2011
Drug reaction with eosinophilia and systemic symptoms (DRESS): a multiorgan antiviral T cell response.
Science translational medicine 2010 Aug 25;2;46ra62 2010 Aug 25
Retrospective analysis of 32 pediatric patients with anticonvulsant hypersensitivity syndrome (ACHSS).
Pediatric dermatology 2009;26;536-46 2009
Clinical heterogeneity of drug hypersensitivity.
Toxicology 2005 Apr 15;209;123-9 2005 Apr 15
Carbamazepine hypersensitivity syndrome: report of 4 cases and review of the literature.
Medicine 1995 May;74;144-51 1995 May

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