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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Candesartan
1
VIII.a
Angioedema (may cause UAO, asphyxia and death)
1
Last update :
11/04/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Angiotensin II receptor blockers (ARB) - Sartans
Publications
Treatment of angiotensin receptor blocker-induced angioedema: A case series.
Severe angioedema induced by angiotensin II receptor blocker.
Angioedema: 6 years experience with fourteen cases.
Angioedema, angiotensin converting enzyme inhibitors, and angiotensin receptor blocking drugs.
Angioedema associated with candesartan.