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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)
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XVI.d
Imaging: Alveolar opacities or haze with a batwing or butterfly distribution
2
Last update :
21/08/2013
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Immunoglobulins, intravenous (IVIG)
Lymphocyte (donor) infusion
Platelet transfusion
Publications
Transfusion-related acute lung injury: an uncommon cause of pulmonary edema.
Radiographic manifestations of transfusion-related acute lung injury.