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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)

5

XV.at Path: Pulmonary capillary granulocyte sequestration

1
Last update : 05/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Immunoglobulins, intravenous (IVIG)
3
Lymphocyte (donor) infusion
1
Platelet transfusion
2

Publications

Neutrophils contain cholesterol crystals in transfusion-related acute lung injury (TRALI).
American journal of clinical pathology 2013 Aug;140;170-6 2013 Aug
The pathology of transfusion-related acute lung injury.
American journal of clinical pathology 1999 Aug;112;216-21 1999 Aug

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