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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)
5
XV.at
Path: Pulmonary capillary granulocyte sequestration
1
Last update :
05/10/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Immunoglobulins, intravenous (IVIG)
Lymphocyte (donor) infusion
Platelet transfusion
Publications
Neutrophils contain cholesterol crystals in transfusion-related acute lung injury (TRALI).
The pathology of transfusion-related acute lung injury.