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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)

5

II.b ARDS - Acute lung injury

5

See under 'TRALI'

Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Immunoglobulins, intravenous (IVIG)
3
Lymphocyte (donor) infusion
1
Platelet transfusion
2

Publications

Late Presentation of Transfusion-related Acute Lung Injury in the Emergency Department.
Clinical practice and cases in emergency medicine 2019 Feb;3;33-35 2019 Feb
Acute respiratory failure during routine blood transfusion: a case report and review of the literature.
The Journal of emergency medicine 2014 Mar;46;341-4 2014 Mar
A case of transfusion-related acute lung injury induced by anti-human leukocyte antigen antibodies in acute leukemia.
The Korean journal of hematology 2012 Dec;47;302-6 2012 Dec
Transfusion-related acute lung injury: from bedside to bench and back.
Blood 2011 Feb 03;117;1463-71 2011 Feb 03
The transfusion of neutrophil-specific antibodies causes leukopenia and a broad spectrum of pulmonary reactions.
Transfusion 2007 Mar;47;545-50 2007 Mar
Transfusion-related acute lung injury.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2007 Jul 17;177;149-50 2007 Jul 17

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