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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)

5

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2
Last update : 14/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Immunoglobulins, intravenous (IVIG)
3
Lymphocyte (donor) infusion
1
Platelet transfusion
2

Publications

Successful eradication of inhibitor in a patient with severe haemophilia B and anaphylaxis to factor IX concentrates: is there a role for Rituximab and desensitization therapy?
Haemophilia : the official journal of the World Federation of Hemophilia 2013 Nov;19;e382-5 2013 Nov
Adverse effects of plasma transfusion.
Transfusion 2012 May;52 Suppl 1;65S-79S 2012 May
Risks of transfusion.
Southern medical journal 2011 Nov;104;762-9 2011 Nov
Anaphylaxis from passive transfer of peanut allergen in a blood product.
The New England journal of medicine 2011 May 19;364;1981-2 2011 May 19
Drug-induced anaphylaxis : case/non-case study based on an italian pharmacovigilance database.
Drug safety 2005;28;547-56 2005
[Lethal anaphylactic shock during the transfusion of a thrombocyte concentrate].
Schweizerische medizinische Wochenschrift 1966 Jul 16;96;918-20 1966 Jul 16

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