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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)

5

II.a Pulmonary edema, noncardiogenic (NCPE)

3
Last update : 09/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Immunoglobulins, intravenous (IVIG)
3
Lymphocyte (donor) infusion
1
Platelet transfusion
2

Publications

Recent insights into the mechanism of transfusion-related acute lung injury.
Current opinion in hematology 2011 Nov;18;436-42 2011 Nov
Complications of massive transfusion.
Chest 2010 Jan;137;209-20 2010 Jan
Transfusion-related acute lung injury: current concepts for the clinician.
Anesthesia and analgesia 2009 Mar;108;770-6 2009 Mar

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