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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Leukotriene receptor antagonists (LTRA)

3

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

2
Last update : 14/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Montelukast
2
Pranlukast
2
Zafirlukast
2

Publications

Churg-Strauss and montelukast.
International journal of immunopathology and pharmacology 2011;24;1079-82 2011
Montelukast and Churg-Strauss syndrome.
Swiss medical weekly 2004 Jun 26;134;377-80 2004 Jun 26
Pulmonary eosinophilia associated with montelukast.
Thorax 1999 Jun;54;558-60 1999 Jun
Churg-Strauss syndrome after zafirlukast in two patients not receiving systemic steroid treatment.
Lancet (London, England) 1999 Feb 27;353;725-6 1999 Feb 27

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