Pneumotox » Drug » Statins » XI.b - Chest pain (acute or subacute), lone or prominent

Statins

XI.b Chest pain (acute or subacute), lone or prominent

Statins can induce acute relapsing lone chest pain simulating pleuritic chest pain or AMI. Occasionnally, chest pain develops in association with statin-induced ILD (PMID 11547251, 16788504)

Last update : 01/02/2019

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

Statins

XI.b Chest pain (acute or subacute), lone or prominent

Publications