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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Lenalidomide
2
I.b
Pneumonitis (ILD)
1
Last update :
20/01/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pomalidomide
Thalidomide
Publications
Lenalidomide Induced Late-Onset Acute Respiratory Distress Syndrome.
Pulmonary toxicity after long-term treatment with lenalidomide in two myeloma patients.
Reversible pulmonary toxicity due to lenalidomide.
Interstitial pneumonitis associated with the immunomodulatory drugs thalidomide and lenalidomide.
Drug-induced interstitial pneumonitis due to low-dose lenalidomide.
Lenalidomide-associated pneumonitis in patients with plasma cell dyscrasias.
Lenalidomide-induced interstitial lung disease.
A case of lenalidomide-induced hypersensitivity pneumonitis.
Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.
Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma.
