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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Daptomycin

3

XIX.c BAL: An excess proportion of eosinophils

1
Last update : 07/01/2020
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antibiotics
5

Publications

Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm.
Open forum infectious diseases 2022 Nov;9;ofac577 2022 Nov
Acute Eosinophilic Pneumonia: A Rare Complication of Daptomycin Therapy.
Cureus 2020 Jan 28;12;e6803 2020 Jan 28
Unexpected Outcome of Daptomycin-induced Eosinophilic Pneumonia: Rarity Within a Rarity.
Cureus 2019 Dec 02;11;e6271 2019 Dec 02

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