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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Leflunomide

3

X.a DRES syndrome - DRESS-like reaction

1
Last update : 04/01/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Leflunomide-induced DRESS syndrome with renal involvement and vasculitis.
Clinical rheumatology 2013 May;32;689-93 2013 May
An unusual case of DRESS syndrome due to leflunomide.
BMJ case reports 2011 Sep 04;2011; 2011 Sep 04
[Drug hypersensitivity syndrome induced by leflunomide].
Annales de dermatologie et de venereologie 2003 May;130;551-2 2003 May

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