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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Zafirlukast

2

X.h Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

2
Last update : 22/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Montelukast
2
Pranlukast
2

Publications

Churg-strauss syndrome: clinical symptoms, complementary investigations, prognosis and outcome, and treatment.
Seminars in respiratory and critical care medicine 2011 Jun;32;298-309 2011 Jun
Leukotriene modifiers and Churg-Strauss syndrome: adverse effect or response to corticosteroid withdrawal?
Drug safety 1999 Oct;21;241-51 1999 Oct
Churg-Strauss syndrome after zafirlukast in two patients not receiving systemic steroid treatment.
Lancet (London, England) 1999 Feb 27;353;725-6 1999 Feb 27
Churg-Strauss syndrome associated with zafirlukast.
The Journal of the American Osteopathic Association 1998 May;98;275-8 1998 May
Churg-Strauss syndrome associated with zafirlukast.
Chest 1998 Jul;114;332-4 1998 Jul

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