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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Streptokinase

2

II.b ARDS - Acute lung injury

1
Last update : 13/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
3
Anticoagulants, oral (vitamin K antagonists-VKA)
5
Superwarfarins (vitamin K super antagonist rodenticides)
4
Thrombolytic (fibrinolytic) agents
3

Publications

Adult respiratory distress syndrome after streptokinase.
The American journal of cardiology 1992 Dec 15;70;1632-3 1992 Dec 15
Pulmonary dysfunction associated with streptokinase therapy.
Archives of surgery (Chicago, Ill. : 1960) 1986 Jul;121;852-3 1986 Jul
Adult respiratory distress syndrome following thrombolytic therapy for pulmonary embolism.
Chest 1983 Jan;83;151-3 1983 Jan

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