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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Pranlukast

2

X.h Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

2
Last update : 12/09/2012
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Montelukast
2
Zafirlukast
2

Publications

Churg-Strauss syndrome and the leukotriene receptor antagonist pranlukast.
Clinical rheumatology 2005 Nov;24;661-2 2005 Nov
The Churg-Strauss syndrome after pranlukast treatment in a patient not receiving corticosteroids.
Annals of internal medicine 2003 Sep 02;139;386-7 2003 Sep 02
Churg-Strauss syndrome may be induced by leukotriene modifiers in severe asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2003 Jul;91;98 2003 Jul
Churg-Strauss syndrome (CSS) in a patient receiving pranlukast.
Clinical rheumatology 2003 Dec;22;491-2 2003 Dec
Churg-Strauss syndrome after reduction of inhaled corticosteroid in a patient treated with pranlukast for asthma.
Internal medicine (Tokyo, Japan) 2001 May;40;432-4 2001 May
Leukotriene modifiers and Churg-Strauss syndrome: adverse effect or response to corticosteroid withdrawal?
Drug safety 1999 Oct;21;241-51 1999 Oct
Churg-Strauss syndrome after corticosteroid withdrawal in an asthmatic patient treated with pranlukast.
The Journal of allergy and clinical immunology 1999 Mar;103;534-5 1999 Mar

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