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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nonsteroidal anti-inflammatory drugs (NSAIDs)

5

X.a DRES syndrome - DRESS-like reaction

1
Last update : 13/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aspirin (Salicylate-ASA) - Aspirin containing drugs
5
Celecoxib
2
Diclofenac
2
Fenbufen
1
Fenoprofen
1
Ibuprofen
3
Ketoprofen
1
Ketorolac
1
Loxoprofen
1
Mefenamic acid
1
Meloxicam
1
Naproxen
2
Oxyphenbutazone
1
Phenylbutazone
2
Piroxicam
1
Pranoprofen
1
Propafenone
1

Publications

Drug reaction with eosinophilia and systemic symptoms syndrome is not uncommon and shows better clinical outcome than generally recognised.
Allergologia et immunopathologia 2015;43;19-24 2015
The DRESS syndrome: a literature review.
The American journal of medicine 2011 Jul;124;588-97 2011 Jul
Clinical features of drug-induced hypersensitivity syndrome in 38 patients.
Journal of investigational allergology & clinical immunology 2010;20;556-62 2010
Drug rash with eosinophilia and systemic symptoms after ibuprofen intake.
Journal of investigational allergology & clinical immunology 2007;17;347-8 2007

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