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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Anticoagulants, oral (vitamin K antagonists-VKA)

5

IV.af Calcification of tracheobronchial cartilaginous rings

1
Last update : 14/07/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Acenocoumarol
1
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
3
Brodifacoum
4
Coumadin
1
Dicoumarol
1
Heparin
4
Heparin, low-m.w.
1
Phenprocoumon
1
Superwarfarins (vitamin K super antagonist rodenticides)
4
Thrombolytic (fibrinolytic) agents
3
Warfarin
5

Publications

Tracheal calcification.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2008 Jul 29;179;291 2008 Jul 29
CT detection of tracheobronchial calcification in an 18-year-old on maintenance warfarin sodium therapy: cause and effect?
AJR. American journal of roentgenology 2000 Sep;175;921-2 2000 Sep
Tracheal and bronchial cartilaginous rings: warfarin sodium-induced calcification.
Radiology 1992 Aug;184;437-9 1992 Aug

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