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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Anticoagulants, oral (vitamin K antagonists-VKA)

5

VIII.b Hematoma of/around central airway wall potentially causing UAO

2
Last update : 18/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Acenocoumarol
1
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
3
Brodifacoum
4
Coumadin
1
Dicoumarol
1
Heparin
4
Heparin, low-m.w.
1
Phenprocoumon
1
Superwarfarins (vitamin K super antagonist rodenticides)
4
Thrombolytic (fibrinolytic) agents
3
Warfarin
5

Publications

Upper airway hematoma: An unusual presentation of acute upper airway obstruction.
Respiratory medicine case reports 2022;36;101612 2022
Images in Clinical Medicine. Spontaneous Retropharyngeal Hematoma.
The New England journal of medicine 2016 Jan 21;374;e3 2016 Jan 21
Warfarin induced sublingual hematoma: a Ludwig angina mimic.
American journal of otolaryngology 2015;36;84-6 2015
Massive sublingual hematoma secondary to anticoagulant therapy complicated by a traumatic denture: a case report.
Journal of medical case reports 2012 Apr 10;6;105 2012 Apr 10
Images in clinical medicine. Lingual hematoma after thrombolytic therapy.
The New England journal of medicine 2011 Feb 17;364;e13 2011 Feb 17
[Sublingual haematoma: an unusual complication of oral anticoagulation therapy: about one case].
Annales francaises d'anesthesie et de reanimation 2008 Jan;27;94-6 2008 Jan
Upper airway obstruction by sublingual hematoma: a complication of anticoagulation therapy with acenocoumarol.
American journal of otolaryngology 2006;27;129-32 2006
Case of sublingual hematoma threatening airway obstruction.
Medical science monitor : international medical journal of experimental and clinical research 2003 Nov;9;CS95-7 2003 Nov
[Dyspnea caused by spontaneous hematoma of the oropharynx and larynx during marcumar therapy].
HNO 2001 Mar;49;220-3 2001 Mar
Coumadin-induced lingual hemorrhage mimicking angioedema.
The American journal of medicine 2000 Jul;109;77-8 2000 Jul
[Upper airway obstruction--a rare complication after anti-coagulant therapy].
Harefuah 1993 Mar 15;124;336-8, 391 1993 Mar 15
[Spontaneous mediastinal hematoma during therapy with oral anticoagulants].
Giornale italiano di cardiologia 1990 Oct;20;972-5 1990 Oct
Upper airway obstruction secondary to warfarin-induced sublingual hematoma.
Archives of otolaryngology--head & neck surgery 1989 Jun;115;718-20 1989 Jun
Upper-airway obstruction as a complication of oral anticoagulation therapy.
Critical care medicine 1986 Sep;14;830-1 1986 Sep
Upper airway obstruction as a complication of oral anticoagulation therapy. Report of three cases.
Archives of internal medicine 1979 Oct;139;1151-3 1979 Oct
Upper airway obstruction induced by warfarin sodium.
Archives of otolaryngology (Chicago, Ill. : 1960) 1976 Aug;102;505-6 1976 Aug
Unusual complications in the course of anticoagulant therapy.
The American journal of medicine 1969 Mar;46;460-3 1969 Mar

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