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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Anticoagulants, oral (vitamin K antagonists-VKA)

5

V.e Hemothorax - Serosanguineous pleural effusion

1
Last update : 16/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Acenocoumarol
1
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
3
Brodifacoum
4
Coumadin
1
Dicoumarol
1
Heparin
4
Heparin, low-m.w.
1
Phenprocoumon
1
Superwarfarins (vitamin K super antagonist rodenticides)
4
Thrombolytic (fibrinolytic) agents
3
Warfarin
5

Publications

Spontaneous hemothorax: a comprehensive review.
Chest 2008 Nov;134;1056-1065 2008 Nov
Anterior mediastinal haematoma and left haemothorax on well-controlled oral anticoagulant therapy.
Postgraduate medical journal 1983 Feb;59;95-7 1983 Feb
Hemothorax as a complication of anticoagulant therapy in the presence of pulmonary infarction.
JAMA 1969 Jun 09;208;1830-4 1969 Jun 09

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