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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Anticoagulants, oral (vitamin K antagonists-VKA)

5

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

2
Last update : 16/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Acenocoumarol
1
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
3
Brodifacoum
4
Coumadin
1
Dicoumarol
1
Heparin
4
Heparin, low-m.w.
1
Phenprocoumon
1
Superwarfarins (vitamin K super antagonist rodenticides)
4
Thrombolytic (fibrinolytic) agents
3
Warfarin
5

Publications

Diffuse Alveolar Hemorrhage Associated with Warfarin Therapy.
Case reports in medicine 2015;2015;350532 2015
Diffuse alveolar hemorrhage in immunocompetent patients: etiologies and prognosis revisited.
Respiratory medicine 2012 Jul;106;1021-32 2012 Jul
Diffuse alveolar hemorrhage with acute respiratory distress syndrome associated with phenprocoumon therapy.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2008 Dec;19;813-5 2008 Dec
Sirolimus-associated diffuse alveolar hemorrhage in a renal transplant recipient on long-term anticoagulation.
Clinical nephrology 2007 Oct;68;238-44 2007 Oct
Alveolar hemorrhage associated with warfarin therapy: a case report and literature review.
The international journal of cardiovascular imaging 2004 Apr;20;155-9 2004 Apr
Acute dyspnea, chest tightness, and anemia in a 33-year-old man.
Chest 1995 Mar;107;863-5 1995 Mar
[Occult intrapulmonary hemorrhage caused by anticoagulants].
Annales de l'anesthesiologie francaise 1981;22;53-6 1981
Occult pulmonary hemorrhage in anticoagulated patients.
The American review of respiratory disease 1975 Jul;112;23-9 1975 Jul

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