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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Anticoagulants, oral (vitamin K antagonists-VKA)

5

V.n Hemopericardium - Bloody pericardial effusion

2
Last update : 11/08/2015
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Acenocoumarol
1
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
3
Brodifacoum
4
Coumadin
1
Dicoumarol
1
Heparin
4
Heparin, low-m.w.
1
Phenprocoumon
1
Superwarfarins (vitamin K super antagonist rodenticides)
4
Thrombolytic (fibrinolytic) agents
3
Warfarin
5

Publications

Hemopericardium and cardiac tamponade associated with warfarin therapy.
Cleveland Clinic journal of medicine 1993;60;336-8 1993
[Hemorrhagic tamponade attributed to treatment with antivitamin K].
La Revue de medecine interne 1992;13;323 1992
ANTICOAGULANT-INDUCED HEMOPERICARDIUM WITH TAMPONADE: ITS OCCURRENCE IN THE ABSENCE OF MYOCARDIAL INFARCTION OR PERICARDITIS.
The New England journal of medicine 1965 Apr 01;272;670-4 1965 Apr 01

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