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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Anticoagulants, oral (vitamin K antagonists-VKA)

5

VIII.a Angioedema (may cause UAO, asphyxia and death)

1
Last update : 18/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Acenocoumarol
1
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
3
Brodifacoum
4
Coumadin
1
Dicoumarol
1
Heparin
4
Heparin, low-m.w.
1
Phenprocoumon
1
Superwarfarins (vitamin K super antagonist rodenticides)
4
Thrombolytic (fibrinolytic) agents
3
Warfarin
5

Publications

Acute airway obstruction due to spontaneous intrathyroid hemorrhage precipitated by anticoagulation therapy.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2014 Dec;18;825-7 2014 Dec
Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.
The American journal of geriatric pharmacotherapy 2008 Aug;6;173-7 2008 Aug
Coumadin-induced lingual hemorrhage mimicking angioedema.
The American journal of medicine 2000 Jul;109;77-8 2000 Jul

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