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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Minocycline

4

V.d Pleural/pericardial effusion, ANA positive (DI lupus)

2
Last update : 29/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antibiotics
5
Doxycycline
1
Minocycline (topical, transdermal)
1
Tetracycline
1

Publications

Minocycline-induced lupus: clinical features and response to rechallenge.
Rheumatology (Oxford, England) 2001 Mar;40;329-35 2001 Mar
Minocycline induced autoimmune disease in rheumatoid arthritis: a missed diagnosis?
The Journal of rheumatology 2001 Feb;28;377-8 2001 Feb
Respiratory distress due to minocycline-induced pulmonary lupus.
Chest 1999 May;115;1471-3 1999 May
Minocycline-induced lupus in adolescents.
Pediatrics 1998 May;101;926 1998 May
Minocycline induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome.
BMJ (Clinical research ed.) 1996 Jan 20;312;169-72 1996 Jan 20
Serious adverse reactions induced by minocycline. Report of 13 patients and review of the literature.
Archives of dermatology 1996 Aug;132;934-9 1996 Aug

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