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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Abciximab

3

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

3
Last update : 09/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Antiplatelet agents: Glycoprotein IIb/IIIa inhibitors
3
Clopidogrel
2
Dabigatran
2
Tiopronine
1

Publications

Be aware of misdiagnosis tied to COVID-19 focusing: a case report of abciximab-induced alveolar haemorrhage thought to be SARS-CoV-2 in a patient with ST-segment elevation myocardial infarction.
European heart journal. Case reports 2020 Dec;4;1-6 2020 Dec
Abciximab-induced alveolar hemorrhage treated with rescue extracorporeal membranous oxygenation.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2015 Apr;85;828-31 2015 Apr
Pulmonary hemorrhage and acute pulmonary thromboembolism after abciximab administration.
The American journal of emergency medicine 2013 Feb;31;450.e1-2 2013 Feb
A retrospective analysis and case series of glycoprotein IIb/IIIa inhibitor associated diffuse alveolar hemorrhage: two case reports.
Cases journal 2009 Jul 30;2;8553 2009 Jul 30
Abciximab-induced alveolar hemorrhage after percutaneous coronary intervention.
The Canadian journal of cardiology 2008 Feb;24;149-51 2008 Feb
A case report of alveolar haemorrhage associated with severe thrombocytopenia induced by abciximab infusion in a patient with an acute coronary syndrome.
Internal and emergency medicine 2008 Dec;3;345-7 2008 Dec
Alveolar hemorrhage: an underdiagnosed complication of treatment with glycoprotein IIb/IIIa inhibitors.
Journal of interventional cardiology 2006 Aug;19;356-63 2006 Aug
Abciximab and fatal pulmonary hemorrhage.
Heart & lung : the journal of critical care 2006;35;423-6 2006
Fatal pulmonary haemorrhage with the combined use of abciximab and fibrinolytic agent.
Singapore medical journal 2002 Nov;43;587-9 2002 Nov
Pulmonary hemorrhage after percutaneous coronary intervention with abciximab therapy.
Mayo Clinic proceedings 2002 Dec;77;1340-3 2002 Dec
Alveolar hemorrhage as a complication of treatment with abciximab.
Chest 2001 Jul;120;126-31 2001 Jul
Diffuse alveolar hemorrhage following administration of tirofiban or abciximab: a nemesis of platelet glycoprotein IIb/IIIa inhibitors.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2000 Feb;49;181-4 2000 Feb
Fatal alveolar hemorrhage and Abciximab (ReoPro) therapy for acute myocardial infarction.
Catheterization and cardiovascular diagnosis 1998 Jul;44;313-6 1998 Jul

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