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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Mesalazine-Mesalamine-5-aminosalicylic acid-5-ASA

4

XII.d Myocarditis (can be fulminant)

1
Last update : 10/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Balsalazide
1

Publications

A Review of Extraintestinal Manifestations & Medication-Induced Myocarditis and Pericarditis in Pediatric Inflammatory Bowel Disease.
Cureus 2022 Jun;14;e26366 2022 Jun
5-Aminosalicylic Acid-induced Myocarditis in a Patient with Atypical Ulcerative Colitis.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2022 Jan 25;79;31-34 2022 Jan 25
A Rare Case of Mesalazine-Induced Acute Myocarditis in a 19-Year-Old Female With Ulcerative Colitis.
Cureus 2021 Nov;13;e20036 2021 Nov
Recurrent mesalazine-induced myopericarditis in a patient with ulcerative colitis.
BMJ case reports 2019 Feb 01;12; 2019 Feb 01
Mesalamine-Induced Myopericarditis: A Case Report and Literature Review.
Cardiology research 2019 Feb;10;59-62 2019 Feb
Successful Treatment of Acute Fulminant Eosinophilic Myocarditis in a Patient with Ulcerative Colitis Using Steroid Therapy and Percutaneous Cardiopulmonary Support.
Internal medicine (Tokyo, Japan) 2019 Apr 15;58;1111-1118 2019 Apr 15
Myocarditis Secondary to Mesalamine-Induced Cardiotoxicity in a Patient with Ulcerative Colitis.
Case reports in medicine 2018;2018;9813893 2018
Recurrent mesalazine-induced myopericarditis in a patient with ulcerative colitis.
Journal of cardiovascular ultrasound 2012 Sep;20;154-6 2012 Sep
Mesalazine-induced myopericarditis in a patient with ulcerative colitis.
International journal of colorectal disease 2006 Mar;21;199-200 2006 Mar
Adverse events in patients treated with 5-aminosalicyclic acid: 1993-1994 pharmacovigilance report for Pentasa in France.
Alimentary pharmacology & therapeutics 1996 Dec;10;949-56 1996 Dec
Giant cell myocarditis: monocytic immunophenotype of giant cells in a case associated with ulcerative colitis.
Human pathology 1995 Jan;26;121-3 1995 Jan
The lung in inflammatory bowel disease.
Medicine 1993 May;72;151-83 1993 May
Fatal myocarditis associated with mesalazine.
Lancet (London, England) 1990 Mar 10;335;605 1990 Mar 10

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