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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Lipids (parenteral)

3

VI.e Fat/oil embolism - The FES embolism syndrome

2
Last update : 27/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Parenteral nutrition
2

Publications

Acute respiratory distress following intravenous injection of an oil-steroid solution.
Canadian respiratory journal 2011;18;e59-61 2011
Acute lung injury probably associated with infusion of propofol emulsion.
Anaesthesia 2007 Aug;62;835-7 2007 Aug
Microvascular pulmonary emboli secondary to precipitated crystals in a patient receiving total parenteral nutrition: a case report and description of the high-resolution CT findings.
Chest 1999 Mar;115;892-5 1999 Mar
Pulmonary intravascular lipid in neonatal necropsy specimens.
Archives of disease in childhood 1991 Jan;66;26-8 1991 Jan
Pulmonary lipid emboli in association with long-term hyperalimentation.
Human pathology 1986 Jan;17;83-5 1986 Jan

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