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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Aminorex

5

VI.b Pulmonary arterial hypertension

4
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amphetamine (and -derivatives)
3
Anorexigens - Anorectic agents - Appetite suppressants
4
Cocaine
5
Dexfenfluramine
3
Fenfluramine
3
Levamisole
4
Levamisole-adulterated/tainted cocaine
5
Para (4) methyl-aminorex
1

Publications

Aminorex associated with possible idiopathic pulmonary hypertension in a cocaine user.
Forensic science international 2014 Jul;240;e7-10 2014 Jul
Aminorex poisoning in cocaine abusers.
International journal of cardiology 2012 Jul 26;158;344-6 2012 Jul 26
Recreational use of aminorex and pulmonary hypertension.
Chest 2000 Nov;118;1496-7 2000 Nov
Aminorex, dexfenfluramine, and primary pulmonary hypertension.
Journal of clinical epidemiology 1998 Apr;51;361-4 1998 Apr
Primary pulmonary hypertension and fenfluramine use.
British heart journal 1993 Dec;70;537-41 1993 Dec
[Chronic pulmonary hypertension of vascular etiology, plexogenic pulmonary arteriopathy and the appetite depressant Aminorex: lessons from an epidemic].
Schweizerische medizinische Wochenschrift 1985 Jun 15;115;818-27 1985 Jun 15
Aminorex and pulmonary hypertension. A review.
Cor et vasa 1985;27;160-71 1985
Long-term follow-up of pulmonary hypertension in patients with and without anorectic drug intake.
Cor et vasa 1985;27;111-24 1985
Pulmonary hypertension, "plexogenic pulmonary arteriopathy" and the appetite depressant drug aminorex: post or propter?
Bulletin europeen de physiopathologie respiratoire 1979;15;897-923 1979
[Reversible pulmonary arterial hypertension after medication of aminorexfumarate (author's transl)].
Medizinische Klinik 1977 Oct 14;72;1685-8 1977 Oct 14
Pulmonary hypertension related to aminorex intake. Histologic, ultrastructural, and morphometric studies of 37 cases in Switzerland.
Current topics in pathology. Ergebnisse der Pathologie 1977;64;1-64 1977
[Apparently primary pulmonary arterial hypertension in a woman who had taken appetite depressants (Aminorex)].
Revue de tuberculose et de pneumologie 1972;36;944-51 1972
Aminorex and the pulmonary circulation.
Thorax 1971 May;26;262-70 1971 May
Drug-induced pulmonary hypertension?
British medical journal 1971 Jan 30;1;265-6 1971 Jan 30

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