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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Aminoglycoside antibiotics

2

IX.a Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

2
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amikacin
1
Antibiotics
5

Publications

Unmasking and exacerbation of myasthenia gravis by ophthalmic solutions: betoxolol, tobramycin, and dexamethasone. A case report.
Muscle & nerve 1997 May;20;631 1997 May
Antibiotics and neuromuscular function.
Anesthesiology 1981 Aug;55;148-59 1981 Aug

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