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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fentanyl analogs/derivatives/substituted

5

XI.r Death following exposure or poisoning

5
Last update : 21/02/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Acetylfentanyl
1
Acrylfentanyl
1
Butyrfentanyl
2
Carfentanyl (carboxymethoxyfentanyl)
2
Fentanyl
5
Fentanyl (smoked, snorted, insufflated, inhaled)
2
Fentanyl (topical)
3
Remifentanil
1
Sufentanil
2

Publications

Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis.
The Journal of pharmacology and experimental therapeutics 2019 Nov;371;453-475 2019 Nov
Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review.
Neuropharmacology 2018 May 15;134;121-132 2018 May 15
Epidemic of deaths from fentanyl overdose.
BMJ (Clinical research ed.) 2017 Sep 28;358;j4355 2017 Sep 28
Deaths Involving Fentanyl, Fentanyl Analogs, and U-47700 - 10 States, July-December 2016.
MMWR. Morbidity and mortality weekly report 2017 Nov 03;66;1197-1202 2017 Nov 03

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