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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Gliptins
2
VIII.a
Angioedema (may cause UAO, asphyxia and death)
2
Last update :
09/03/2016
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Angiotensin II receptor blockers (ARB) - Sartans
Angiotensin converting enzyme inhibitors (ACEI)
Dipeptidyl peptidase-4 inhibitors
Linagliptin
Saxagliptin
Sitagliptin
Vildagliptin
Publications
Dipeptidyl Peptidase-4 Inhibitor Induced Angioedema - An Overlooked Adverse Drug Reaction?
Angioedema induced by cardiovascular drugs: new players join old friends.