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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fenfluramine

3

VI.b Pulmonary arterial hypertension

4
Last update : 28/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aminorex
5
Amphetamine (and -derivatives)
3
Cocaine
5
Dexfenfluramine
3
Levamisole
4

Publications

Pulmonary arterial hypertension associated with fenfluramine exposure: report of 109 cases.
The European respiratory journal 2008 Feb;31;343-8 2008 Feb
Pulmonary arterial hypertension in France: results from a national registry.
American journal of respiratory and critical care medicine 2006 May 01;173;1023-30 2006 May 01
Aminorex to fen/phen: an epidemic foretold.
Circulation 1999 Jan 5-12;99;156-61 1999 Jan 5-12
Primary pulmonary hypertension associated with the use of fenfluramine derivatives.
Chest 1998 Sep;114;195S-199S 1998 Sep
Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence.
JAMA 1997 Aug 27;278;666-72 1997 Aug 27
Drug-induced pulmonary hypertension: must history repeat itself?
Pulmonary pharmacology 1996 Apr;9;67-8 1996 Apr
Pulmonary hypertension and dexfenfluramine.
European journal of clinical pharmacology 1995;48;81-3 1995
Irreversible pulmonary hypertension after treatment with fenfluramine.
British medical journal (Clinical research ed.) 1986 Jul 05;293;51-2 1986 Jul 05
Irreversible pulmonary hypertension after treatment with fenfluramine.
British medical journal (Clinical research ed.) 1986 Jan 25;292;239-40 1986 Jan 25
Irreversible pulmonary hypertension after treatment with fenfluramine.
British medical journal (Clinical research ed.) 1986 Apr 26;292;1137 1986 Apr 26
Long-term follow-up of pulmonary hypertension in patients with and without anorectic drug intake.
Cor et vasa 1985;27;111-24 1985
Pulmonary hypertension and fenfluramine.
British medical journal (Clinical research ed.) 1981 Oct 03;283;881-3 1981 Oct 03

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