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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fenfluramine

3

XII.b Valvular heart disease and/or dysfunction

3
Last update : 10/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aminorex
5
Amphetamine (and -derivatives)
3
Cocaine
5
Dexfenfluramine
3
Levamisole
4

Publications

Valvular heart disease with the use of fenfluramine-phentermine.
Texas Heart Institute journal 2011;38;581-3 2011
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
Circulation 2000 Dec 05;102;2836-41 2000 Dec 05
Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999 Sep;23;926-8 1999 Sep
Valvular heart disease associated with fenfluramine-phentermine.
The New England journal of medicine 1997 Dec 11;337;1772; author reply 1775 1997 Dec 11
Valvular heart disease associated with fenfluramine-phentermine.
The New England journal of medicine 1997 Aug 28;337;581-8 1997 Aug 28

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