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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Allopurinol

1

X.a DRES syndrome - DRESS-like reaction

1
Last update : 06/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Rapidly Progressing Severe Cutaneous Adverse Reaction With Acute Kidney Injury After Drug Exposure: An Uncommon Presentation.
American journal of therapeutics 2016;23;e916-9 2016
Drug reaction with eosinophilia and systemic symptoms syndrome is not uncommon and shows better clinical outcome than generally recognised.
Allergologia et immunopathologia 2015;43;19-24 2015
Allopurinol-induced DRESS syndrome.
Indian journal of pharmacology 2012 May;44;412-4 2012 May
The DRESS syndrome: a literature review.
The American journal of medicine 2011 Jul;124;588-97 2011 Jul
Allopurinol causing drug rash with eosinophilia and systemic symptoms syndrome: a challenging diagnosis.
International journal of general medicine 2011;4;789-92 2011
Allopurinol-induced DRESS syndrome.
The Israel Medical Association journal : IMAJ 2005 Oct;7;656-60 2005 Oct
[Life-threatening adverse effects of pharmacologic antihyperuricemic therapy].
Therapeutische Umschau. Revue therapeutique 2004 Sep;61;575-7 2004 Sep
[Allopurinol induced DRESS syndrome].
La Revue de medecine interne 2004 Mar;25;252-4 2004 Mar

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