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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Oil-/lipid-based formulations (parenteral)
3
II.b
ARDS - Acute lung injury
1
Last update :
21/02/2015
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anabolic androgenic steroids
Doxorubicin (pegylated-liposomal)
Excipients, erroneously/deliberately administered i.v.
Excipients-Vehicle-Preservatives (of drugs)
Lipiodol - Iodinated/iodized oil (RCM)
Olive oil
Progesterone
Synthol
Testosterone cypionate
Testosterone undecanoate
Publications
Fat embolism syndrome caused by vegetable oil injection.
