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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Doxorubicin - Adriamycin

3

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

1
Last update : 04/07/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Anthracyclines
5
Transhepatic arterial chemoembolization (TACE)
3

Publications

Early and late arrhythmogenic effects of doxorubicin.
Southern medical journal 2007 Mar;100;262-5 2007 Mar
[ECG changes in adriamycin therapy].
Acta medica Austriaca. Supplement 1979;6;339-41 1979
Adriamycin-induced cardiac dysrhythmias in an experimental dog model.
Cancer treatment reports 1978 Jun;62;963-78 1978 Jun

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