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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Doxorubicin - Adriamycin

3

XII.s Heart block (bundle branch- or AV-)

1
Last update : 23/06/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Anthracyclines
5
Transhepatic arterial chemoembolization (TACE)
3

Publications

Rare complication of doxorubicin-induced complete heart block in a patient with Hodgkin's lymphoma: a case report.
European journal of hospital pharmacy : science and practice 2023 Sep;30;e26 2023 Sep
Doxorubicin-induced second degree and complete atrioventricular block.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2005 May;7;227-30 2005 May
[ECG changes in adriamycin therapy].
Acta medica Austriaca. Supplement 1979;6;339-41 1979

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