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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Obinutuzumab
1
Last update :
22/03/2014
I - Interstitial/parenchymal lung disease
I.b
Pneumonitis (ILD)
1
X - Systemic/Distant conditions, syndromes and reactions
X.g
Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)
1
XVII - Infections & related conditions
XVII.b
Opportunistic pulmonary/systemic infections
1
XVII.r
Fungal infection (pulmonary/extrapulmonary)
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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