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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Radiofrequency pulmonary ablation
3
Large series at PMID 24793688
Last update :
06/05/2014
I - Interstitial/parenchymal lung disease
I.y
Progression, acceleration or exacerbation of preexisting ILD/fibrosis
1
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.a
Alveolar hemorrhage (AH), diffuse AH (DAH)
1
V - Pleural and/or pericardial involvement
V.e
Hemothorax - Serosanguineous pleural effusion
1
XVII - Infections & related conditions
XVII.a
Respiratory tract infection incl. pneumonia
1
XVII.p
Lung abscess/abscesses (see also VIr)
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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