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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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See also under 'Chemicals'
Last update :
18/03/2018
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.a
Alveolar hemorrhage (AH), diffuse AH (DAH)
1
IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.d
Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)
5
XII - Cardiovascular involvement / toxicity
XII.m
Cardiac- cardiorespiratory/pulmonary arrest
1
XIV - Hemoglobinopathies - Abnormal hemoglobin states (acquired)
XIV.c
Carboxyhemoglobinemia
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Chemicals
Glyphosate
Organophosphates
Paraquat
Rodenticides
Terrorism and bioterrorism agents