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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Fluoropyrimidines
3
Last update :
25/10/2018
II - Pulmonary edema - Acute lung injury - ARDS
II.d
Pulmonary edema, cardiogenic
1
XII - Cardiovascular involvement / toxicity
XII.c
Pericardial effusion (w/wo tamponade)
1
XII.f
Cardiomyopathy (acute, subacute, chronic)
2
XII.g
Coronary artery disease (acute) - Myocardial ischemia/infarction
2
XII.l
Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
2
XII.ai
Cardiotoxicity
2
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Capecitabine
Fluorouracil (5-FU)