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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Lithium, lithium poisoning
1
Last update :
25/03/2022
II - Pulmonary edema - Acute lung injury - ARDS
II.b
ARDS - Acute lung injury
1
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.c
Upper airway obstruction other than angioedema or hematoma
1
XII - Cardiovascular involvement / toxicity
XII.d
Myocarditis (can be fulminant)
1
XII.s
Heart block (bundle branch- or AV-)
1
XII.x
Sinus arrest
1
XII.ai
Cardiotoxicity
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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