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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Ribavirin
1
See also under interferons
Last update :
20/09/2012
I - Interstitial/parenchymal lung disease
I.a
Pneumonitis (ILD), acute and/or severe (may cause ARDS)
-
IV - Airway involvement
IV.a
Bronchospasm - Wheezing - Asthma
-
IV.d
Cough (lone)
1
IV.w
Plugs/casts in the airways
1
IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.h
Dyspnea, unexplained otherwise
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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