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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dabrafenib-Trametinib combination therapy (BRAFi)

1
Last update : 08/03/2020
I - Interstitial/parenchymal lung disease

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1

I.b Pneumonitis (ILD)

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I.m ILD with a granulomatous component

1
X - Systemic/Distant conditions, syndromes and reactions

X.k Sarcoid-like granulomatosis (endo-/extrathoracic)

1

X.ah Granulomatosis with polyangiitis (typically ANCA pos.) - GPA flare

1
XV - Pathology

XV.e Path: ILD with a granulomatous component (see also Im)

1

XV.ba Path: Granulomatous lymphadenopathy

1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Dabrafenib
1
Trametinib
1

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