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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Endobronchial ultrasound (EBUS) guided biopsy
2
Last update :
20/02/2022
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.h
Major/massive hemoptysis
1
VII - Mediastinal involvement
VII.h
Pneumomediastinum
1
VII.i
Mediastinitis
2
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.c
Upper airway obstruction other than angioedema or hematoma
1
XII - Cardiovascular involvement / toxicity
XII.c
Pericardial effusion (w/wo tamponade)
1
XII.be
Septic/purulent pericardial effusion
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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